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Prioritize Protein While historic guidelines suggested people aim for 0.81 gram of lean proteins (like eggs, wild-caught fish, poultry, or grass-fed beef) per pound of body weight, Eberwein recommendsand recent science supports 7 a higher protein intake: 1.21.6 g per kilogram of body weight to blunt the muscle-loss signal during a calorie deficit, especially in midlife and older adults

For a comparison of these medications, check our GLP-1 receptor agonists list

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This enhanced efficacy is due to semaglutides unique ability to strongly bind to GLP-1 receptors, thereby effectively controlling appetite, slowing digestion, and helping patients feel full longer

On average, volunteers in the retatrutide clinical trial who received the study drug rather than a placebo lost an average of 70.3 pounds over about a year-and-a-half, with more than 45% of participants losing more than 30% of their body weight